Action potential from nerve reach neuromuscular junction. Acetylcholine is released from the neuron and is bound by nicotinic receptors on muscle cell, eventually cause rise of intracellular calcium, which are released from sarcoplasmic reticulum. Calcium ions bind to troponin, which releases its inhibition on myosin. Myosin is now allowed to bind to actin. Myosin head bind to actin and flex, shortening the sarcomere (this is called the powerstroke, sometimes). ATP is hydrolyzed to release myosin from actin, and the head revert back to ordinary position. The cycle repeats to shorten the sarcomere even further. This causes the muscle to contract.
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